The present study deals with Phytochemical and Anthelminthic evaluation of fruits of Piper nigrum. Extraction of Piper nigrum was investigated for their Anthelmintic activity against PheritimaPhostima at various concentrations(200- 400mg/30ml) of each extract was tested in paralysis time and the death time of the organisms. It was performed invitro screening against PheritimaPhostima.Theethanolic extract exhibited a maximum anthelminthic activity comparable to standard drug Albendazole (20mg/ml) and isolated Piperine. The hydro alcoholic (3:2)andhydro alcoholic extracts(1:1) shows modest activity. The preliminary phytochemical analysis indicated the presence of various phytoconstituents in all tested extracts. In proceeding to the research approach literature revealed the toxic nature of other chemical agent, so work directed towards herbal and phytomedicine.Alkaloids shows significant cidal effect on pheritimaphostima. ThePiperine alkaloid was isolated authenticated and characterized by TLC andSpectroscopic methods respectively.

Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its case of administration and the belief that oral administration of the drug is well absorbed. All the pharmaceutical products formulated for systemic delivery via the oral route of administration irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage forms (either solid dispersion or liquid), must be developed within the intrinsic characteristics of GI physiology, pharmacokinetics, pharmacodynamics and formulation design is essential to achieve a systemic approach to the successful development of an oral pharmaceutical dosage form.

Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. It has been reported that Dysphagia (difficulty in swallowing) is common among all age groups and more specific with pediatric, geriatric population along with institutionalized patients and patients with nausea, vomiting, and motion sickness complications. ODTs with good taste and flavor increase the acceptability of bitter drugs by various groups of population. Orally disintegrating tablets are also called as orodispersible tablets, quick disintegrating tablets, mouth dissolving tablets, fast disintegrating tablets, fast dissolving tablets, rapid dissolving tablets, porous tablets, and rapimelts. However, of all the above terms, United States pharmacopoeia (USP) approved these dosage forms as ODTs.

The aim of the present study was to develop and characterize sustained release pellets of Ambroxol HCl using Ethyl cellulose 7cps and Ethyl cellulose 50cps.The pellets were prepared by Wurster process with EC 7cps in 0.5%w/w, 1%w/w and 1.5%w/w and EC 50cps at 2%w/w, 3.5%w/w and 5%w/w.Then the pellets were evaluated for bulk density, angle of repose and Carr’s index. The pellets were characterized for particle size by sieving technology and particle surface, surface texture by SEM analysis. The in-vitro dissolution studies were carried out using 0.1N HCl for first 2hrs followed by phosphate buffer of pH 6.8 up to 24h with USP-II dissolution apparatus. The mean dissolution time was found to be increased by increasing Ethyl cellulose levels. From one way ANOVA it was found that the ratio of binary polymer mixture had significant (p < 0.05) effect on drug release. The data were fitted to various kinetic models. The data fitted well in both Higuchi and Hixon-crowel model.