Volume-1, Issue-2
Evaluation of Hepato Protective Activity of Methanolic Stem Bark Extract of Mangifera indica in Rats
P. Sravan Kumar*, P. Ramesh
The present study was undertaken to evaluate the effect of methanolic stem bark extract of mangifera indica for its hepatoprotectivity activity. It was evaluated in normal and INH, rifampsin induced hepato toxic rats. Liv.52 was used as a standard drug at a dose of 500mg/kg body wt given in oral route. Albino wistar rats with INH’s rifampsin induced hepato toxicity were divided in to 4 groups of 6 each in the study. Hepatoprotective effect as two different doses (200 & 400 mg/ kg body wt PO) of MEMI will be investigated for 28 days to evaluate dose dependant activity. Effect of MEMI on SGPT , SGOT, ALP, total cholesterol, total bilirubin, were investigated for Zero day, 7th, 14th, 21st, 28th day and anti oxidant parameters were checked on 28th day of the scarification.
Stability Indicating RP - HPLC Method Development and Estimation of Zidovudine Tablet
Srujan Reddy*, Ramesh Guptha
A simple, precise, accurate, and rapid reverse phase-high performance liquid chromatography (RP-HPLC) method with UV-Visible detector has been developed and estimation of Zidovudine tablet dosage form.
A Commodious Synthesis, Modelling and Docking Studies of Strontium ranelate for the treatment of Osteoporosis
Jayasree yadav.V*, Nagamani.C, Keerthi kumar.B, Ramesh gupta
Post-menopausal Osteoporosis is the most common form of osteoporosis and usually affects women over the age of 60. It leads to bone loss as well as brittle bones that lead to breakage. Owing to this happening not only the quality of life is affected but also it causes the alarming rate of deaths. In other words, it paves a path for inevitable. If we ascertain the probable causes of such phenomena the following are, if the female have menopause; they have an eating disorder severe enough to stop their periods; they lost their height in the past 10 years; they used steroids more than 6 months; there was a family history of osteoporosis etc., this disease was discovered in time the condition can be treated with a variety of different drugs that are in the market, otherwise it is unreliable to cure the disease.
